I strongly promote settling on a “family” of guns as your primary defensive handgun option. Personally, I use the Glock 9mm family, in particular the Glock 19 and Glock 26. I don’t bother with the small-frame Glocks like the model 43 because they don’t accept the standard magazines. Being restricted to model specific single-stack magazines is my biggest turnoff regarding single stack models. I find that accommodating the slightly wider gun, such as the model 26, is completely worthwhile due to the enhanced capability the double-stack magazine provides. The flush fit 10 round magazine for the Glock 26 can easily be swapped for a 12, 15, 17, 21, or 33 round magazine. The versatility is amazing, thus the Glock 26 remains my primary carry gun. I can make it quite tiny, or I can load it up so that it gives up relatively little to a service-sized pistol.
I used to carry a Glock 19 most of the time and I still use one often, and the 19 is my preferred house gun. Obviously, a Glock 17 or 34 make wonderful house guns as well, as the larger size is only a plus rather than a negative if the gun is not a concealment piece. Such magazine compatibility makes this line of handgun exceedingly versatile. The Glock line, however, is not the only handgun family with such magazine compatibility. The Smith and Wesson M&P and the Sig P320 lines also work in this manner, as do many other handgun families. In my mind, the double-stack 9mm, in all of its size deviations, serves as the go-to self-defense tool of the contemporary age.
G17 for my home defense gun in a FAS1 safe that is bolted to my bed frame. I keep a couple spare magazines there as well. G26 carry and it goes in the safe at night (laying in the bottom to the side of the G17 that is in the safe’s holster. My wife can access it if I get the G17 out for any reason. Magazine interchangeability and common controls were a big factor when I chose this home and carry setup many years ago.
That is a great lineup. I find the G19 and G26 serve all of my needs and both can accept all of the extended options as well.